文部科学省科学研究費補助金　新学術領域研究（研究領域提案型） 　先端技術を駆使したHLA多型・進化・疾病 　に関する統合的研究 　（領域略称名　HLA進化と疾病）　　 　領域代表者　九州大学高等研究院・笹月健彦
	ホーム	領域概要	研究組織	活動	研究成果	ニュース	リンク
	論文発表（2010－2012Aug） A01 1. Suzuki M, Meguro A, Ota M, Nomura E, Kato T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, *Mizuki N: Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma. Mol Vis. 16: 1874-1879, 2010. 2. Kurata R, Nakaoka H, Tajima A, Hosomichi K, Shiina T, Meguro A, Mizuki N, Ohono S, Inoue I, *Inoko H: TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26. Biochem Biophys Res Commun 401: 533-537, 2010. 3. Morishima S, Ogawa S, Matsubara A, Kawase T, Nannya Y, Kashiwase K, Satake M, Saji H, Inoko H, Kato S, Kodera Y, Sasazuki T, *Morishima Y: Japan Marrow Donor Program. Impact of highly conserved HLA haplotype on acute graft-versus-host disease. Blood 115: 4664-4670, 2010. 4. Aarnink A, Estrade L, Apoil PA, Kita YF, Saitou N, Shiina T, *Blancher A: Study of Cynomolgus monkey (Macaca fascicularis) DRA polymorphism in four populations. Immunogenetics 62: 123-136, 2010. 5. Terabayashi Y, Morita K, Park JY, Saito S, Shiina T, Inoko H, Ishiwata I, Fujimori KE, *Hirano T. Construction of Japanese BAC library Yamato-2 (JY2): a set of 330K clone resources of damage-minimized DNA taken from a genetically established Japanese individual. Hum Cell 24:135-145, 2011. 6. Mitsunaga S, Homma Y, Narita A, Kashiwase K, Okudaira Y, Shiina Y, Inoue I, *Inoko H: Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population. Hum Immunol 72: 566-570, 2011. 7. *Shiina T, Kono A, Westphal N, Suzuki S, Hosomichi K, Kita YF, Roos C, Inoko H, Walter L: Comparative genome analysis of the major histocompatibility complex (MHC) class I B/C segments in primates elucidated by genomic sequencing in common marmoset (Callithrix jacchus). Immunogenetics 63: 485-99, 2011. 8. Ohta Y, Shiina T, Lohr RL, Hosomichi K, Pollin TI, Heist EJ, Suzuki S, Inoko H, *Flajnik MF: Primordial linkage of β2-microglobulin to the MHC. J Immunol 186: 3563-3571, 2011. 9. Kobayashi C, Shiina T, Tokioka A, Hattori Y, Komori T, Kobayashi-Miura M, Takizawa T, Takahara K, Inaba K, Inoko H, Takeya M, Dranoff G, *Sugita M: GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice. J Invest Dermatol 132: 241-244, 2011. 10. *Kulski JK, Shigenari A, Inoko H: Genetic variation and hitchhiking between structurally polymorphic Alu insertions and HLA-A, -B, and -C alleles and other retroelements within the MHC class I region. Tissue Antigens 78: 359-377, 2011. 11. Kita YF, Ando A, Tanaka K, Suzuki S, Ozaki Y, Uenishi H, Inoko H, Kulski JK, *Shiina T: Application of high-resolution, massively parallel pyrosequencing for estimation of haplotypes and gene expression levels of swine leukocyte antigen (SLA) class I genes. Immunogenetics 64:187-199, 2012. 12. Arikata M, * Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y, Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K: Memory Immune Responses against Pandemic (H1N1) 2009 Influenza Virus Induced by a Whole Particle Vaccine in Cynomolgus Monkeys Carrying Mafa-A1*052∶02. PLoS One 7: e37220, 2012. 13. Oka A, Mabuchi T, Ozawa A, *Inoko H: Current understanding of human genetics and genetic analysis of psoriasis. J Dermatol 39: 231-241, 2012. 14. Mitsunaga S, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Narita A, Kashiwase K, Okudaira Y, Inoue I, Kulski JK, *Inoko H: Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis. Tissue Antigens 80: 16-25, 2012. 15. 鈴木進悟、尾崎有紀、吉川枝里、重成敦子、岡晃、光永滋樹、椎名隆、*猪子英俊、次世代シークエンサーを用いたHLAクラスI遺伝子の超高解像度DNAタイピング (Super high resolution Single molecule - Sequence Based Typing; SS-SBT) 法の開発、MHC、19: 43-53, 2012. 16. Harkensee C, Oka A, Onizuka M, Middleton PG, Inoko H, Hirayasu K, Kashiwase K, Yabe T, Nakaoka H, Gennery AR, Ando K, *Morishima Y: Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study. Blood 2012 May 14. [Epub ahead of print] 17. Hara Y, and *Imanishi T Abundance of ultramicro inversions within local alignments between human and chimpanzee genomes. BMC Evolutionary Biology 11: 308, 2012. 18. Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, Gu D, Zhu D, Haiman CA, Mo Z, Gao YT, Saw SM, Go MJ, Takeuchi F, Chang LC, Kokubo Y, Liang J, Hao M, Le Marchand L, Zhang Y, Hu Y, Wong TY, Long J, Han BG, Kubo M, Yamamoto K, Su MH, Miki T, Henderson BE, Song H, Tan A, He J, Ng DP, Cai Q, Tsunoda T, Tsai FJ, Iwai N, Chen GK, Shi J, Xu J, Sim X, Xiang YB, Maeda S, Ong RT, Li C, Nakamura Y, Aung T, Kamatani N, Liu JJ, Lu W, Yokota M, Seielstad M, Fann CS; The Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Wu JY, Lee JY, Hu FB, Tanaka T, Tai ES, *Shu XO. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 44: 307-311, 2012. 19. Nakabayashi K, Tajima A, Yamamoto K, Takahashi A, Hata K, Takashima Y, Koyanagi M, Nakaoka H, Akamizu T, Ishikawa N, Kubota S, Maeda S, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Sasazuki T, *Shirasawa S. Identification of independent risk loci for Graves’ disease within the MHC in the Japanese population. J Hum Genet 56: 772-778, 2011. 20. Cho YS, Chen CH, Hu C, Long J, Ong RTH, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma R, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee J, Lee N, Li Y, Liu J, Lu W, Nakamura J, Nakashima E, Ng DPK, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho N, Chang TJ, Bao Y, Hedman A, Morris A, McCarthy M, DIAGRAM CONSORTIUM, MuTHER consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan J, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke K, Kato N, Han BG, *Seielstad M. East Asian Genome-Wide Association Meta-Analysis Identifies 8 New Loci for Type 2 Diabetes. Nat Genet 44: 67-72, 2011. 21. Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson JE, Chen YT, Miki T, Zhou X, Sugiyama T, Jeon JP, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Zhang X, Wong TY, Han BG, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu JY, Teo YY, Tai ES, Cho YS, *He J. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet 43: 531-538, 2011. 22. Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, Yasumi T, Tauchi H, Koh K, Sato M, Morimoto A, Heike T, *Ishii E, Yasukawa M. Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes. PLoS One. 5: e14173, 2010. A02 1. *Mazaki Y, Nishimura Y, Sabe H: GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol Biol Cell in press 2. TanakaT., *Nakayama H., Yoshitake Y., Irie A., Nagata M., Kawahara K., Takamune Y., Yoshida R., Nakagawa Y., Ogi H., Shinriki S., Ota K., Hiraki A., Ikebe T., Nishimura Y., Shinohara M. : Selective inhibition of nuclear factor-κB by nuclear factor-κB essential modulator-binding domain peptide suppresses the metastasis of highly metastatic oral squamous cell carcinoma. Cancer science 103: 455-463, 2012. 3. Yonekawa T., Matsushita T., Minohara M., Isobe N., Masaki K., Yoshimura S., Nishimura, Y., *Kira, J.-I.: T cell reactivities to myelin protein-derived peptides in neuromyelitis optica patients with anti-aquaporin-4 antibody. Neurology Asia 16: 139-142, 2011. 4. Woo KC, Kim TD, Lee KH, Kim DY, Kim S, Lee HR, Kang HJ, Chung SJ, Senju S, Nishimura Y, *Kim KT: Modulation of exosome-mediated mRNA turnover by interaction of GTP binding protein 1 (GTPBP1) with its target mRNAs. FASEB Journal 25: 2757-2769, 2011. 5. *Senju S, Haruta M, Matsumura K, Matsunaga Y, Fukushima S, Ikeda T, Takamatsu K, Irie A, Nishimura Y: Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapy. Gene Therapy 18: 874-883, 2011. 6. Imai K, Hirata S, Irie A, Senju S, Ikuta Y, Yokomine K, Harao M, Inoue M, Tomita Y, Tsunoda T, Nakagawa H, Nakamura Y, Baba H, *Nishimura Y: Identification of HLA-A2-restricted CTL epitopes of a novel tumor-associated antigen, KIF20A, overexpressed in pancreatic cancer. Brit J Cancer 104: 300-307, 2011. 7. Tomita Y, Harao M, Senju S, Imai K, Hirata S, Irie A, Inoue M, Hayashida Y, Yoshimoto K, Shiraishi, K, Mori T, Nomori H, Kohrogi H, *Nishimura Y: Peptides derived from human insulin-like growth factor (IGF)-II mRNA binding protein 3 can induce human leukocyte antigen-A2-restricted cytotoxic T lymphocytes reactive to cancer cells. Cancer Science 102: 71-78, 2011. 8. Tomita Y, Imai K, Senju S, Irie A, Inoue M, Hayashida Y, Shiraishi K, Mori T, Daigo Y, Tsunoda T, Ito T, Nomori H, Nakamura Y, Kohrogi H, *Nishimura Y: A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T lymphocytes reactive to tumor cells. Cancer Science 102: 697-705, 2011. 9. *Senju S, Matsunaga Y, Fukushima S, Hirata S, Motomura Y, Fukuma D, Matsuyoshi H, Nishimura Y: Immunotherapy with pluripotent stem cell-derived dendritic cells. Seminars in Immunopathology 33: 603–612, 2011. 10. Obayashi T, Irie A, Murakami Y, Nowak M, Potempa J, Nishimura Y, Shinohara M, *Imamura T：Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus. Microbiology 157: 786-792, 2011. 11. Ikeda T, Hirata S, Fukushima S, Matsunaga Y, Ito T, Uchino M, *Nishimura Y *Senju S: Dual effects of TRAIL to suppress autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells. J Immunol 185: 5259-5267, 2010. 12. Inoue, M, Senju S, Hirata S , Ikuta Y, Hayashida Y, Irie A, Harao M, Imai K, Tomita Y, Tsunoda T, Furukawa Y, Ito T, Nakamura Y, Baba H, *Nishimura, Y: Identification of SPARC as a candidate target antigen for immunotherapy of various cancers. Int J Cancer 127: 1393-1403, 2010. 13. Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida,Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y, *Nishimura Y: The Forkhead Box M1 Transcription Factor, as a Possible Immunotherapeutic Tumor-Associated Antigen. Int J Cancer 126: 2153-2163, 2010. 14. Isobe N, Matsushita T, Yamasaki R, Ramagopalan S, Kawano Y, Nishimura Y, Ebers G, *Kira JI: Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status. Multiple Sclerosis 16: 147-155, 2010. 15. Chen YZ, Liu G, Senju S, Wang Q, Irie A, Haruta M, Matsui M, Yasui F, Kohara M, *Nishimura Y: Identification of SARS-CoV spike protein-derived and HLA-A2-restricted human CTL epitope by using a new muramyl dipeptide-derivative adjuvant. International Journal of Immunopathology and Pharmacology 23: 165-177, 2010. 16. *Senju S, Hirata S, Motomura Y, Fukuma D, Matsunaga Y, Fukushima S, Matsuyoshi H, Nishimuran Y: Pluripotent stem cells as source of dendritic cells for immune therapy. Int J Hematol 91: 392–400, 2010. 17. *Senju S, Matsunaga,Y, Fukushima S, Hirata S, Matsuyoshi H, Nishimura Y: Pluripotent stem cell-derived dendritic cells for immunotherapy.　Frontiers in bioscience (Elite edition) 2, pp. 1520-1527, 2010.　 18. *Miyagawa T, Miyadera H, Tanaka S, Kawashima M, Shimada M, Honda Y, Tokunaga K, Honda M*: Abnormally low serum acylcarnitine levels in narcolepsy patients.　Sleep 34: 349-353A. 2011. 19. Goto Y, Ogawa K, Hattori A, *Tsujimoto M: Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma. J Biol Chem 286: 21906-21914, 2011. 20. Goto Y, Yoshioka R, Arisaka N, Hattori A, *Tsujimoto M: Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q. Biol Pharm Bull 34: 24-27, 2011. 21. Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, *Stratikos E: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme. J Immunol 186: 1909-1913, 2011. 22. Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, *Stratikos E: Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J 435: 411-420, 2011. 23. *Waditee-Sirisattha R, Hattori A, Shibato J, Rakwal R, Sirisattha S, Takabe T, Tsujimoto M: Role of the Arabidopsis leucine aminopeptidase 2. Plant Signal Behav 6: 1581-1583, 2011. 24. *Waditee-Sirisattha R, Shibato J, Rakwal R, Sirisattha S, Hattori A, Nakano T, Takabe T, Tsujimoto M: The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response. New Phytol 191: 958-969, 2011. 25. Ohno Y, *Hattori A, Ueda M, Kageyama S, Yoshiki T, Kakeya H*: Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene. FEBS J 278: 4088-4099, 2011. 26. Hattori A, Goto Y, *Tsujimoto M: Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1. Biol Pharm Bull 35: 601-605, 2012. 27. Horie A, *Fujiwara H, Sato Y, Suginami K, Matsumoto H, Maruyama M, Konishi I, Hattori A: Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation. Hum Reprod 27: 1267-1276, 2012. 28. *Hattori A, Maruyama M, Fujiwawra H, Tsujimoto M: Aminopeptidase Q/Laeverin. In Handbook of Proteolytic Enzymes, 3rd Edn: Rawlings N and Salvesen G (ed) Elsevier. in press, 2012. 29. Zhang L, Udaka K, Mamitsuka H, *Zhu S: Toward more accurate pan-specific MHC-peptide binding current methods and tools. Brief Bioinform 13: 350-364, 2012. 30. 食と健康のための免疫学入門 「第10章　がんとペプチドワクチン」宇高恵子　p.177-198　京都健康フォーラム監修　上野川修一・吉川正明編集 建帛社　2012 31. ドラッグデリバリーシステムの新展開ＩＩ　–核酸医薬・抗体医薬を支えるＤＤＳ技術- 「第4章　ワクチンへの展開　4.　ペプチドがんワクチン」宇高恵子　P.181-188 監修：永井恒司、岡田弘晃　シーエムシー出版　2012 A03 1. Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Arase H, Tokunaga K, Patarapotikul J, *Yabe T: Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. PLoS Pathogens 8: e1002565, 2012. 2. Naka I, Nishida N, *Ohashi J: No evidence for strong recent positive selection favoring the 7 repeat allele of VNTR in the DRD4 gene. PLoS ONE 6: e24410, 2011. 3. 大橋　順. Extended Haplotype Homozygosity (EHH)を用いる正の自然選択検出法の検出力比較. 統計数理（in press）. 4. *Nonaka MI, Aizawa K, Mitani H, Bannai HP, Nonaka M: Retained orthologous relationships of the MHC class I genes during euteleost evolution. Mol Biol Evol 28: 3099-3112, 2011. 5. Fujito NT, *Nonaka M: Highly divergent dimorphic alleles of the proteasome subunit beta type-8 (PSMB8) gene of the bichir Polypterus senegalus. Immunogenetics 64: 447-453, 2012. 6. Tsukamoto K, Fujito NT, Yoshizaki G, *Nonaka M: Long-lived dichotomous lineages of the proteasome subunit beta type 8 (PSMB8) gene surviving more than 500 million years as alleles or paralogs. Mol Biol Evol in press, 2012. A04 1. *Miyagawa T, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, Tokunaga K.: Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. Journal of Human Genetics 55: 63-65, 2010. 2. Shimada M, *Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K.:An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Human Genetics 128: 433-441, 2010. 3. Toyoda H, *Tanaka S, Miyagawa T, Honda Y, Tokunaga K, Honda M.: Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy. Sleep 33: 875-878, 2010. 4. Yuliwulandari R, Sachrowardi Q, Nakajima F, Kashiwase K, Hirayasu K, Mabuchi A, Salam A M, *Tokunaga K: Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia. Human Immunology 71: 697-701, 2010. 5. Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, *Mignot E: Common variants in P2RY11 are associated with narcolepsy. Nature Genetics 43: 66-71, 2011. 6. *Miyagawa T, Miyadera H, Tanaka S, Kawashima M, Shimada M, Honda Y, Tokunaga K, *Honda M: Abnormally low serum acylcarnitine levels in narcolepsy patients. Sleep 34: 349-353, 2011. 7. *Sugihara S, Ogata T, Kawamura T, Urakami T, Takemoto K, Kikuchi N, Takubo N, Tsubouchi K, Horikawa R, Kobayashi K, Kasahaera Y, Kikuchi T, Koike A, Mochizuki T, Minamitani K, Takaya R, Mochizuki H, Nishii A, Yokota I, Kizaki Z, Mori T, Shimura N, Mukai T, Matsuura N, Fujisawa T, Ihara K, Kosaka K, Kizu R, Takahashi T, Matsuo S, Hanaki K, Igarashi Y, Sasaki G, Soneda S, Teno S, Kanzaki S, Saji H, Tokunaga K, Amemiya, S, The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT):HLA-class II and class I genotypes among Japanese children with Type1A diabetes and their families. Pediatric Diabetes 13: 33-44, 2012. 8. Ozaki A, *Inoue Y, Hayashida K, Nakajima T, Honda M, Usui A, Komada Y, Kobayashi M, Takahashi K.: Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: Comparison between patients on psychostimulants, durug-naïve patients and the general Japanese population. Sleep Medicine 13: 200-206, 2012. 9. Scammell TE, Matheson JK, Honda M, Thannickal TC, *Siegel JM: Coexistence of narcolepsy and Alzheimer’s disease. Neurobiology of Aging 33:1318-1319, 2012. 10. Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Parham P, Arase H, Tokunaga K, Patarapotikul J, *Yabe T: Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. PLoS Pathogens 8: e1002565, 2012. 11. Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl E, Kurreman F, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthigton J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, *Yamamoto K: Meta-analysis of genome-wide association studies identifies multiple novel loci associated with rheumatoid arthritis in the Japanese population. Nature Genetics 44: 511-517, 2012. 12. Nakabayashi K, Tajima A, Yamamoto K, Takahashi A, Hata K, Takashima Y, Koyanagi M, Nakaoka H, Akamizu T, Ishikawa N, Kubota S, Maeda S, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Sasazuki T, *Shirasawa S. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. J Hum Genet 56: 772-778, 2011. 13. Doi K, Fujimoto T, Koyanagi M, Tsunoda T, Tanaka Y, Yoshida Y, Takashima Y, Kuroki M, Sasazuki T, *Shirasawa S. ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts. Cell Mol Biol Lett. 16: 89-100, 2011. 14. Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, Koyanagi M, Yoshida Y, Okamura T, Kuroki M, Sasazuki T, *Shirasawa S. Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Proc Natl Acad Sci U S A. 107: 14199-141204, 2010. 15. Yoshida Y, Tsunoda T, Takashima Y, Fujimoto T, Doi K, Sasazuki T, Kuroki M, Iwasaki A, Shirasawa S. ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model. Cell Mol Biol Lett. 15: 541-550, 2010. 16. Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 75: 291-455, 2010. Review. 17. Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J. An update to HLA nomenclature, 2010. Bone Marrow Transplant 45: 846-848, 2010. 18. Morishima S, Ogawa S, Matsubara A, Kawase T, Nannya Y, Kashiwase K, Satake M, Saji H, Inoko H, Kato S, Kodera Y, Sasazuki T, *Morishima Y; Japan Marrow Donor Program. Impact of highly conserved HLA haplotype on acute graft-versus-host disease. 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